(395) Role of Sherpapak in Donors with Drug Overdose and Long Ischemic Times

PurposeOver the last several years, number of deaths from drug overdose has increased. Heart transplantation (HT) utilizing donor hearts patients dying expanded pool. The current standard method organ procurement includes use an ice cooler (ICE), which adds risk tissue freezing injury. SherpaPak Cardiac Transport System (CTS) is a controlled hypothermic preservation technology that maintains heart temperatures between 4°C - 8°C, potentially mitigating this risk.MethodsThe GUARDIAN registry (October 2015-August 2022) 761 HT 9 US centers in were procured using either CTS or ICE. Subgroup analysis HTs donors who died due to overdose, and whose total ischemic time was > 4 hours performed. outcomes compared performed vs Summary statistics used for comparison.ResultsOur cohort included 26 12 ICE group. cohorts well-matched aside few areas. Significantly fewer recipients had durable VAD at baseline. Additionally, while zero gender mismatches, 8 (30.8%) with 5 (19.2%) female-to-male mismatches. showed trend requiring new post-transplant mechanical circulatory support (MCS) rate more than double (50.0% v 23.1%, p=0.10). primary graft dysfunction (PGD) survival similar (details Table 1).ConclusionThe 30-day two groups. trends towards lower need MCS times hours. Utilizing individuals prolonged appears have trended toward favorable when over Over risk. comparison. Our 1).